{"id":17,"date":"2011-07-09T09:56:00","date_gmt":"2011-07-09T09:56:00","guid":{"rendered":"http:\/\/blog.pinerundental.com\/?p=17"},"modified":"2016-04-08T17:20:02","modified_gmt":"2016-04-08T17:20:02","slug":"genetics-can-be-a-risk-factor-for-dental-implants","status":"publish","type":"post","link":"https:\/\/www.pinerundental.com\/blog\/genetics-can-be-a-risk-factor-for-dental-implants\/","title":{"rendered":"GENETICS CAN BE A RISK FACTOR FOR DENTAL IMPLANTS!"},"content":{"rendered":"

A recent article in the Journal of Oral Implantology has identified a combination of genes that when present may adversely affect dental implants.\u00a0 This could change the way we evaluate patients for dental implant reconstruction. \u00a0<\/span><\/h1>\n

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gary l henkel dds magd<\/span><\/h1>\n

horsham dental elements<\/span><\/h1>\n

www.horshamdentalelements.com<\/span><\/h1>\n

ghenkel@pinerundental.com\u00a0<\/span><\/h1>\n

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Gene combination identified as risk factor in success of dental implants<\/h1>\n

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Jun 29, 2011 <\/span><\/div>\n
Journal of Oral Implantology<\/em> \u2014 The health of the surrounding tissue affects the success of a dental implant<\/a>. Identifying and reducing risk factors is therefore a key step in the implant process. Now a combination of genes has been identified as a possible indicator of greater tissue destruction, leading to negative outcomes for implants<\/a>.
\nThe authors of an article<\/a> in the current issue of the Journal of Oral Implantology<\/em> report on a study of individuals with the combination of interleukin (IL)-1 allele 2 at IL-1A-889<\/sup> and IL-1B+3954<\/sup>. These people are \u201cgenotype positive\u201d and are susceptible to increased periodontal tissue destruction.
\nPeri-implantitis, or the process of tissue inflammation and destruction around failing implants, is very similar to periodontal disease. The researchers sought to find any association of these genotypes with the severity of peri-implantitis progression and the effect of this combination on treatment outcomes.
\nThis study compared two groups of patients, all of whom had implants. The first group consisted of 25 patients with peri-implantitis, while the second group of 25 patients had healthy tissue. Seventeen patients from the first group and five from the second group were genotype positive.
\nPatients in the first group, those with peri-implantitis, took part in a treatment and maintenance program. The genotype-positive patients in this group experienced greater periodontal tissue destruction and, increased discharge from tissues. The genotype-negative patients responded better to treatment. Statistically significant differences were noted between the groups.
\nThe combination of these two alleles in patients with inflamed periodontal tissues denotes a risk factor that can lead to further tissue destruction. Patients with the specific genotype can have exaggerated local inflammation. Gene polymorphism may affect the outcomes of treatment for peri-implantitis in genotype-positive people and affect the long-term success of implants.
\nFull text of the article, \u201cThe Effect of Interleukin-1 Allele 2 Genotype (IL-1a-889<\/sup> and IL-1b+3954<\/sup>) on the Individual\u2019s Susceptibility to Peri-Implantitis: Case-Control Study,\u201d Journal of Oral Implantology<\/em>, Vol. 37, No. 3, 2011, is available by clicking here<\/a>.
\nThe Journal of Oral Implantology<\/em> is the official publication of the American Academy of Implant Dentistry and of the American Academy of Implant Prosthodontics. It is dedicated to providing valuable information to general dentists, oral surgeons, prosthodontists, periodontists, scientists, clinicians, laboratory owners and technicians, manufacturers, and educators. The JOI distinguishes itself as the first and oldest journal in the world devoted exclusively to implant dentistry. For more information about the journal or society, click here<\/a>.
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Source:<\/div>\n
DentistryIQ<\/a><\/div>\n<\/div>\n